Chamberlain Lab

Slide 1

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There are several published studies that have reported links between zDHHC enzymes and cancer. The zDHHC2 gene is present on a region of chromosome 8 (band 8p22) on which potential tumour suppressors for a variety of cancers map. Decreased expression of zDHHC2 has been identified in human cancers, including gastric adenocarcinoma and colorectal cancer. In addition, the zDHHC23 gene (also known as DHHC11) is located on a region of chromosome 5 that exhibits increased copy number in bladder cancers and non-small cell lung cancers. Furthermore, zDHHC9 is up-regulated in certain colorectal tumours.

Research in our group is investigating how zDHHC dysfunction might contribute to or protect from cancer. This work is focussed on identifying key molecular targets of the zDHHC enzymes that have been linked with specific cancers with a view to identifying cellular pathways that are likely to be altered in response to zDHHC expression changes.

Past/Present Sponsors

MRC 

 Wellcome Trust

Diabetes UK

BBSRC

SULSA  

Palmitoylation

Palmitoylation is the most prominent type of S-acylation and involves the covalent and reversible attachment of a 16 carbon saturated fatty acid (palmitic acid) to cysteines of target proteins.